2,4 Dienoyl-CoA reductase - definizione. Che cos'è 2,4 Dienoyl-CoA reductase
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Cosa (chi) è 2,4 Dienoyl-CoA reductase - definizione


2,4 Dienoyl-CoA reductase deficiency         
MEDICAL CONDITION
Dienoyl-CoA reductase deficiency; 2,4 Dienoyl-CoA Reductase Deficiency
2,4 Dienoyl-CoA reductase deficiency is an inborn error of metabolism resulting in defective fatty acid oxidation caused by a deficiency of the enzyme 2,4 Dienoyl-CoA reductase. Lysine degradation is also affected in this disorder leading to hyperlysinemia.
2,4 Dienoyl-CoA reductase         
  •  doi-access = free }}</ref> of DECR with 2,4 Hexadienoyl-CoA and NADPH (not shown). Key residues in the enzyme active site orient the substrate for hydride transfer through a network of hydrogen bonds.
  • Proposed mechanism of 2,4-Trans dienoyl-CoA reduction by NADPH in mammalian DECR. The mechanism proceeds stepwise through an enolate intermediate.
CLASS OF ENZYMES
2,4-dienoyl-CoA reductase (NADPH); 2,4 Dienoyl CoA reductase; Trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase
2,4 Dienoyl-CoA reductase also known as DECR1 is an enzyme which in humans is encoded by the DECR1 gene which resides on chromosome 8. This enzyme catalyzes the following reactions
Hydroxymethylglutaryl-CoA reductase         
CLASS OF ENZYMES
EC 1.1.1.88; (R)-mevalonate:NAD+ oxidoreductase (CoA-acylating); Hydroxymethylglutaryl coa reductase
In enzymology, a Hydroxymethylglutaryl-CoA reductase () is an enzyme that catalyzes the chemical reaction